Parkinson's disease - Symptoms and causes

PARKINSONS DISEASE

⁃ this is the common chronic degenerative disease of the central nervous system that produces progressive movement disorders and changed in congition and mood.
⁃ A pill-polling tremor of hands , muscular rigidity, loss of facial expression, difficulty initiating mocements such as, akinesia, bradykinesia and gait disturbances .
⁃ This disease is mostly found in the people who are over the age of 68.
⁃ CAUSES:-
⁃ Dopamine production by brain cells in the substantia nigra is dimminished in the the disease.
⁃ Clusters in families are often.
⁃ Genetics conditions
⁃ Viruses, toxins or drugs.
⁃ SYMPTOMS:-
⁃ Tremors in one or more extemties when the hand at its rest.
⁃ Fatigue , malaise.
⁃ During sleep decreased Anxiety or stress .
⁃ Change in the vocal quality
⁃ Shuffling gait that becomes faster after a few steps.
⁃ TREATMENT:-
⁃ Maintain the function for ad long as possible and relieve symptoms.
⁃ Administer medications such as,selegine, levodopa/carbidopa:- dopamine agonists .
⁃ Inhibitors of catechol-o-methyltranseferase .
⁃ Monoamine oxidase-B inhibitors.
⁃ Surgical therapy , in which may involve transplantation of dopamine-secreting cells into affected areas of brain or insertion of electricsl brain stimulators into thr subthalamic nucleus .
⁃ Phsyical therapy is given helping to maintain muscle tone and function.

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